NCOG-04. RANO-BM RESPONSE CRITERIA VERIFICATION STUDY IN A SRS-TREATED COHORT

Abstract Brain metastases are frequently seen in neurosurgical practice. Standardised criteria created to better classify these common pathologies research studies. This study’s goal was evaluate RANO-BM (Response Assessment Neuro-Oncology - Metastases) criteria’s current thresholds a cohort of patients with brain managed by stereotactic radiosurgery (SRS). We performed retrospective metastasis-level analysis treated SRS for metastases. The data collected included demographics, characteristics, outcomes, and the rate true positives, false negatives, negatives positives as defined at last follow-up before second SRS. 251 50 were analysis. using yielded sensitivity 38%, specificity 95%, positive predictive value 71% negative 84%. Modified absolute diameter differences 2.5 mm 83%, 87%, 67% 94%. Pseudoprogression occurred significantly earlier than tumor progression, median time onset 6.9 months 12.1 respectively. Current unreliably identifies clinically relevant but useful assessing increases caused progression pseudoprogression.